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Part:BBa_K4877006
Designed by: Team iGEM Bielefeld-CeBiTec 2023 Group: iGEM23_Bielefeld-CeBiTec (2023-10-12)
The part consists of the 5'UTR of the human alpha globin 1 / hemoglobin subunit alpha 1 gene (HBA1; nucleotides 1-31). It does not contain the Kozak sequence.
The 5'UTR of human alpha globin 1 has been reported to be used in mRNA vaccines due to its stabilizing effects on mRNA [1].
[1] Kim, S., Sekhon, S.S., Shin, WR. et al. Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency. Mol. Cell. Toxicol. 18, 1–8 (2022). https://doi.org/10.1007/s13273-021-00171-4
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